Labels:text | screenshot | black and white | black | document OCR: d puberty Most chronic diseases can lead to delay le to In some cases, delay in puberty may be d ith nutritional deficiency and is reversible ses exert improved nutrition. Some chronic dise ine direct destructive effects upon the endo auses system: for example, sickle cell anaemia diseases testicular failure due to ischaemia. Othe ue to their are associated with endocrine disorders for therapy: for example, blood transfusion ng to thalassaemia cause haemosiderosis lead hypothalamic dysfunction.